[marcus]

Saludos:

TEngo 25 años, y por lo que he leido en los foros.., muchos comparten el problema que tengo..., soy nuevo en esto..y he leido bastante, y ya he consultado un dermartologo, el cual me dijo que tenia alopecia androgenetica. Este me receto minoxidil al 5%, junto con un champu llamado Ketoconazol Ketomed.

Pero cuando empeze a leer sobre estos medicamentos, me surgio una gran duda.

El uso de Ketoconazol Ketomed, por le que he leido esta orientado a problemas de hongos y caspa..o cosas asi..., pero no habla de explicitamente del tratamiento en lo referente a la caida del cabello.

De que sirve aplicar este champu, y combinarlo con minoxidil? Que beneficios me trae??.. ...Por que el dermatologo me lo receto?..
Que pasaria si no uso el champu..., y solo uso el minoxidil?.



Finalmente muchas gracias a quien me pueda ayudar. La verdad no tengo idea acerca de estos medicamentos..., y no tengo a quien mas acudir.

Muchas gracias por su ayuda.

[Alex_S_E]

Otros te lo responderán mejor si acaso, pero así a lo pronto el ketoconazol es efectivamente un antifungico y sirve para controlar la seborrea y la dermatitis seborreica, causas también de la caida del cabello, el dermatologo probablemente vio que tenías una de las dos y te lo receto.

[Nico]

Hola como estas !

El champo con ketoconazol es un antifungico, antiseborreico y antiandrogeno suave (funciona como el minox 2% mas o menos)

Acá te dejo un estudio donde explica como funciona en casos de alopecia androgenética:

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of AGA is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA.

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.

PMID: 14729013 [PubMed - indexed for MEDLINE]

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

Saludos !!

[marcus]

Gracias por sus respuestas, me han sacado de una gran duda.

[KAREN646]

HOLA SOY KAREN GUSTO EN SALUDARLES A TODOS Y TODAS!!SOY DE MEXICO BAJA CALIFORNIA!TENGO 21 Y TENGO PROBLEMAS TAMBIEN DE ALOPECIA YA FUI AL DERMATOLOGO Y ME RECETO KETOMED KETOCONAZOL APENAS TENGO COMO 3 DIAS USANDOLO!!AA ESTO DE NO TENER PELO SALE CARO Y ES TRISTE PERO SOY MUY POSITIVA Y SE QUE MI PELO CRECERA COMO ERA ANTES TENGO COMO MENOS DE LO QUE FUERA UNA DIADEMA SIN PELO.DEL LADO IZQUIERDO ARRIBA D MI PATILLA..MI DERMATOLOGO TAMBIEN ME RECETO UNA LOCION QUE ELLOS HACEN DIJO QUE ME LA UNTE POR LAS NOCHES Y ME BANE POR LAS MANANAS DIJO QUE SOY DE LAS PERSONAS QUE NO PUEDO ESTAR SIN LABARME EL PELO Y QUE NO USE ACONDICIONADOR..EN FIN..SUERT A TODOS Y TODAS CON SUS PROBLEMAS!!HAY QUE ANIMARNOS!!QUE PRONTO NUESTRO PELO CRESERA YO LES DIRE COMO ME VA CON EL SHAMPOO OK!!Y SI HAY POR AHI OTRA COSA EN QUE PUEDAN AYDUARME O RECETARME ADELANTE SE LOS AGRADECERE

[Aaron Ibarra]

Hola yo tengo exactamente el mismo problema y le quería preguntar si yo también puedo usar el champoo y q tipo de gel usas para lavarte la cara ya q yo también tengo exactamente el mismo problema en mi cara tengo damaciado sebo al punto de q no salgo de mi casa tengo ya 9 años sin salir de mi casa por esta maldita enfermedad por favor alguien q me pueda ayudar se lo pido de favor

[Nico]

Hola como estas !

Para la cara mejor es que lo consultes con tu dermatologo. Ketoconazol 2% lo podes usar en el cuero cabelludo 3 veces por semana.

Saludos !